Targeting Metastatic Cancer: Disseminated Tumor Cells and Premetastatic Niches

BACKGROUND: Metastases are simply known as cancers spread to another part of the body, and often be responsible for severity cancer prognosis. Somehow, complex mechanisms metastases not fully understood yet.CONTENT: The characteristic is akin a never-healing wound. Cancer cells plastic dynamic they build their niches developed into metastases, even when seem dormant. Therefore, can survive immune system. Recent research has shown distinct biology metastasis-initiating cell, which leads tumor development in distant organs, surveillance evasion, co-option metastatic micro-environments. Effective therapies must consider regenerative states malignancies have careful observation patient phenotypes.SUMMARY: This review aimed provide an insight on genesis characteristics starting from its seeding dormancy, until advance phase. Thus, developing therapy should start it grows, but earlier strategies since primary was detected.KEYWORDS: metastasis, DTC, CTC, CSC, pre-metastatic niche, plasticity